Study was in fact analyzed by about three-ways ANOVA which have pairwise evaluation accompanied by Tukey’s article hoc test

Associations

The primary goal of this study was to analyze urinary Na + , K + and the Na + :K + excretion ratio, for associations with changes in systolic blood pressure (SBP) in participants from the DASH–Sodium trial during the initial screening period in which participants were consuming their regular diet without dietary intervention. The secondary goals of this study were to investigate: (a) the impact of the salt sensitivity of blood pressure on these responses and (b) the impact of the DASH–Sodium dietary intervention, which lowers SBP and increases dietary K + intake, on these potential associations. Our analysis reports that in the DASH–Sodium study cohort: (1) a daily excretion of <1 g K + /day is associated with elevated SBP, (2) urinary K + excretion of >1 g/day does not correlate with a reduction in SBP and, (3) a reduction in the urinary Na + :K + excretion ratio is not associated with lower SBP irrespective of the salt sensitivity of blood pressure. Collectively our data support the recent DRI recommendation not to propose a DRI for K + and suggest that further evidence is required to support the establishment of a Na + /K + excretion ratio that would reduce SBP in the general population.

Logical details

Indicate SBP according to urinary salt so you’re able to potassium (Na + /K + ) removal ratio during examination along with weight-loss input out of Weightloss Ways to Prevent Blood pressure levels (DASH) high salt (HS) and you can lowest salt (LS) eating plan for the (a) sodium delicate (letter = 71), (b) sodium unwilling (letter = 119) someone, thinking revealed given that suggest ± SD.

Significantly, we observed no association between the urinary Na + :K + ratio and SBP on the DASH HS or DASH LS dietary intervention in either SS (DASH HS R 2 = 0.04, DASH LS R 2 = 0.02) or SR (DASH HS R 2 = 0.04, DASH LS R 2 = 0.00002) participants (Fig. 5a, b). The DASH dietary intervention significantly increased the number of participants in both SS and SR groups with a urinary Na + :K + ratio of <1 on both the HS and LS diet. However, the urinary Na + :K + had no impact on SBP within dietary intake groups (Fig. 6a, b). Further, when expressed as a frequency distribution histogram the change in SBP from the DASH HS to LS dietary intervention exhibits a profound leftward shift in the SS group compared to SR group (Fig. 7a). In contrast, the frequency distribution histogram for change in the urinary Na + :K + ratio from the DASH HS to LS dietary intervention shows no difference in the Gaussian curve and distribution between SS and SR participants (Fig. 7b).

Subsequent, multiple studies have suggested your blood pressure prevention evoked because of the K + consumption is influenced by fat loss Na + intake [twenty-eight, 29]. Within research of the Dashboard-Sodium dataset i seen no association with urinary K + excretion and you can SBP, for the patient examination check out or throughout the Dashboard fat loss intervention whenever Na + consumption try changed, suggesting an independence of aftereffects of Na + and K + towards the SBP in this analysis. Brand new 2019 DRI Report determined that there can be insufficient research towards the consequences from K + towards the blood circulation pressure and failed online dating sites to establish an effective DRI out-of K + . The analysis secure the 2019 DRI Statement and signifies that dietary K + supplementation will most likely not significantly treat blood circulation pressure on general people.

Realization

Stamler J, Flower G, Stamler Roentgen, Elliott P, Dyer A, Marmot Meters. INTERSALT research conclusions. Societal health insurance and healthcare effects. Blood pressure levels. 1989;–seven.